Oprd1^tm1Kff
Targeted Allele Detail

Summary

• Symbol: Oprd1^tm1Kff
• Name: opioid receptor, delta 1; targeted mutation 1, Brigitte L Kieffer
• MGI ID: MGI:2387013
• Synonyms: DOR^-, Oprd1^-
• Gene: Oprd1 Location: Chr4:131838037-131871797 bp, - strand Genetic Position: Chr4, 64.78 cM, cytoband D1-D3
• Alliance: Oprd1^tm1Kff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62551
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which encodes the translational start codon, was replaced by a neomycin selection cassette inserted by homologous recombination. A radiolabeled binding assay demonstrated complete functional ablation in homozygous mutant mice. (J:62551)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprd1 Mutation: 30 strains or lines available

References

• Original: J:62551 Filliol D, et al., Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet. 2000 Jun;25(2):195-200
• All: 29 reference(s)