Apc^tm1Hsa
Targeted Allele Detail

Summary

• Symbol: Apc^tm1Hsa
• Name: APC, WNT signaling pathway regulator; targeted mutation 1, Hitoshi Sasai
• MGI ID: MGI:2387050
• Synonyms: Apc^delta474
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1Hsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61978
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Duplication, Insertion
• Apc^tm1Hsa involves 1 genes/genome features (Apc) View all
• Mutation details: The gene was disrupted at exon 9 by insertion of a neo cassette and exons 10, 7, 8, and 9. The insertion and duplication results in a frameshift and premature translation termination. The mutant allele was confirmed by RT-PCR analysis. (J:61978)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm1Hsa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:61978 Sasai H, et al., Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis. 2000 May;21(5):953-8
• All: 3 reference(s)