Tg(Ggamma-T)15Cps
Transgene Detail

Summary

• Symbol: Tg(Ggamma-T)15Cps
• Name: transgene insertion 15, Carlos Perez-Stable
• MGI ID: MGI:2387092
• Synonyms: G gamma/T, Ggamma/T-15
• Transgene: Tg(Ggamma-T)15Cps Location: unknown
• Alliance: Tg(Ggamma-T)15Cps page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the human HBG2 (hemoglobin gamma) promoter and the wild-type allele of the SV40 large T antigen (TAg) gene. In addition to line 15, lines 2 and 21 were produced. (J:79828)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ggamma-T)15Cps

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Prostate gland tumors were observed at 50% frequency in hemizygous males and at 100% frequency in homozygous males.

Three additional founders (2, 20, and 21) showed varying tumor frequencies.

References

• Original: J:79828 Perez-Stable C, Distinct negative regulatory mechanisms involved in the repression of human embryonic epsilon- and fetal G gamma-globin genes in transgenic mice. J Biol Chem. 1994 Dec 30;269(52):33109-15
• All: 6 reference(s)