Crygd^Aey4
Chemically induced Allele Detail

Summary

• Symbol: Crygd^Aey4
• Name: crystallin, gamma D; dominant cataract 4
• MGI ID: MGI:2387106
• Synonyms: Aey4
• Gene: Crygd Location: Chr1:65101031-65102611 bp, - strand Genetic Position: Chr1, 32.8 cM
• Alliance: Crygd^Aey4 page

Morphological description and histological comparison of lenses and eyes of Crygd^Aey4/Crygd^Aey4 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-A transversion at nucleotide position 227 of the cDNA is predicted to result in a substitution of valine at position 76 with an aspartic acid in the encoded protein. This amino acid residue belongs to a structurally conserved region within the second Greek Key motif. (J:78154)
• Inheritance: Dominant

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crygd Mutation: 16 strains or lines available

References

• Original: J:78154 Graw J, et al., V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice. Mamm Genome. 2002 Aug;13(8):452-5
• All: 3 reference(s)