Dct^tm1(cre)Bee
Targeted Allele Detail

Summary

• Symbol: Dct^tm1(cre)Bee
• Name: dopachrome tautomerase; targeted mutation 1, Friedrich Beermann
• MGI ID: MGI:2387116
• Synonyms: Dct^-, Dct^Cre, Dct ^- KO
• Gene: Dct Location: Chr14:118250202-118289656 bp, - strand Genetic Position: Chr14, 61.6 cM
• Alliance: Dct^tm1(cre)Bee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79094
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Dct^tm1(cre)Bee expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dct (MGI:102563)

• Mutation details: Exon 1, which is the first coding exon, was replaced with a cassette containing cre and neo. RT-PCR indicated an absence of normal transcript in homozygous mice. Normal protein was undetected by Western blot analysis of skin extracts and by immunohistochemical analysis of embryonic retinal pigment epithelium. (J:89896)
• Inheritance: Recessive

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dct (mouse) Summary of all recombinase alleles driven by Dct. Comparative matrix view of recombinase activities Alliance mouse Dct gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dct Mutation: 35 strains or lines available

References

• Original: J:79094 Guyonneau L, et al., Expression of cre recombinase in pigment cells. Pigment Cell Res. 2002 Aug;15(4):305-9
• All: 13 reference(s)