Lnpep^tm1Ske
Targeted Allele Detail

Summary

• Symbol: Lnpep^tm1Ske
• Name: leucyl/cystinyl aminopeptidase; targeted mutation 1, Susanna R Keller
• MGI ID: MGI:2387151
• Synonyms: IRAP^-
• Gene: Lnpep Location: Chr17:17747985-17846303 bp, - strand Genetic Position: Chr17, 9.77 cM
• Alliance: Lnpep^tm1Ske page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 6 and their intervening introns were replaced with a neomycin resistance gene. The deleted region included sequence encoding the cytoplasmic tail involved in subcellular localization and regulation, the transmembrane domain, and the zinc binding site that is essential for catalytic activity. Western blot analysis indicated an absence of normal protein in homozygous mutant mice. (J:76570)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lnpep Mutation: 100 strains or lines available

References

• Original: J:76570 Keller SR, et al., Mice Deficient in the Insulin-regulated Membrane Aminopeptidase Show Substantial Decreases in Glucose Transporter GLUT4 Levels but Maintain Normal Glucose Homeostasis. J Biol Chem. 2002 May 17;277(20):17677-86
• All: 10 reference(s)