Erbb2^tm1Klee
Targeted Allele Detail

Summary

• Symbol: Erbb2^tm1Klee
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Kuo-Fen Lee
• MGI ID: MGI:2387154
• Synonyms: erbB2 floxed
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^tm1Klee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76196
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 3.0 kb region containing 1.5 kb of the endogenous promoter and exon 1 was flanked by loxP sites. Exon 1 encodes amino acids 1 through 27. (J:76196)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:76196 Crone SA, et al., ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002 May;8(5):459-65
• All: 9 reference(s)