Hdlq3^SM/J
QTL Variant Detail

Summary

• QTL variant: Hdlq3^SM/J
• Name: HDL QTL 3; SM/J
• MGI ID: MGI:2387165
• QTL: Hdlq3 Location: unknown Genetic Position: Chr18, Syntenic

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased HDL cholesterol concentration on a CHOW diet compared to NZB/BlNJ. (J:76707)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76707

90 female animals from an (SM/J x NZB/BlNJ)F1 x NZB/BlNJ backcross population were screened for an initial set of 78 SSLP markers to identify QTLs associated with HDL cholesterol (HDL-C) concentrations. Parental strain NZB/BlNJ exhibits elevated HDL-C onboth a CHOW and atherogenic diet compared to parental SM/J and F1 hybrid animals. A QTL linked to HDL-C on a CHOW diet, Hdlq3, mapped to 12 cM on mouse Chromosome 18 near D18Mit34 (LOD=3.2). NZB-derived alleles confer increased HDL cholesterol concentrations at Hdlq3. Suggestive loci were also detected near D6Mit44 (48 cM) and D18Mit24 (18 cM) in linkage to inducible HDL-C, and on mouse Chromosome 11 at 14 cM and 44 cM in linkage to non-HDL-C on a CHOW diet and non-HDL-C on an atherogenic diet, respectively.

References

• Original: J:76707 Pitman WA, et al., Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice. Physiol Genomics. 2002;9(2):93-102
• All: 1 reference(s)