Dab2^tm1Cpr
Targeted Allele Detail

Summary

• Symbol: Dab2^tm1Cpr
• Name: disabled 2, mitogen-responsive phosphoprotein; targeted mutation 1, Jonathan A Cooper
• MGI ID: MGI:2387166
• Synonyms: Dab2^fl
• Gene: Dab2 Location: Chr15:6329269-6470193 bp, + strand Genetic Position: Chr15, 2.15 cM, cytoband A2
• Alliance: Dab2^tm1Cpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75911
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2, which encodes the phosphotyrosine binding (PTB) domain common to all known isoforms, was left flanked by single loxP sites after a floxed neo cassette was excised by in vitro cre mediated recombination. (J:75911)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dab2 Mutation: 53 strains or lines available

References

• Original: J:75911 Morris SM, et al., Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 2002 Apr 2;21(7):1555-64
• All: 11 reference(s)