Runx1tm1Dez
Targeted Allele Detail
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Symbol: |
Runx1tm1Dez |
Name: |
runt related transcription factor 1; targeted mutation 1, Dong-Er Zhang |
MGI ID: |
MGI:2387293 |
Synonyms: |
AML1-ETO, Runx1tm1(CBFA2T1)Dez |
Gene: |
Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
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Alliance: |
Runx1tm1Dez page
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Germline Transmission: |
Earliest citation of germline transmission:
J:38705
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A construct containing human exon 5 followed by the entire human CBFA2T1 coding region was inserted at the endogenous locus via homologous recombination, replacing the endogenous exon 5. The targeted allele generates a fusion protein similar to the fusion protein resulting from T(8;21) which is associated with the M2 subtype of acute myeloid leukemia (AML). Transcription of the allele was verified in heterozygous mice by a protection assay.
(J:38705)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Runx1 Mutation: |
34 strains or lines available
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Original: |
J:38705 Yergeau DA, et al., Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet. 1997 Mar;15(3):303-6 |
All: |
1 reference(s) |
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