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Runx1tm1Dez
Targeted Allele Detail
Summary
Symbol: Runx1tm1Dez
Name: runt related transcription factor 1; targeted mutation 1, Dong-Er Zhang
MGI ID: MGI:2387293
Synonyms: AML1-ETO, Runx1tm1(CBFA2T1)Dez
Gene: Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance: Runx1tm1Dez page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38705
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA construct containing human exon 5 followed by the entire human CBFA2T1 coding region was inserted at the endogenous locus via homologous recombination, replacing the endogenous exon 5. The targeted allele generates a fusion protein similar to the fusion protein resulting from T(8;21) which is associated with the M2 subtype of acute myeloid leukemia (AML). Transcription of the allele was verified in heterozygous mice by a protection assay. (J:38705)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  34 strains or lines available
References
Original:  J:38705 Yergeau DA, et al., Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet. 1997 Mar;15(3):303-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory