Tg(Tyrp1-cre)1Ipc
Transgene Detail

Summary

• Symbol: Tg(Tyrp1-cre)1Ipc
• Name: transgene insertion 1, I Pierre Chambon
• MGI ID: MGI:2387296
• Synonyms: Cre^Trp1, TRP1-Cre
• Transgene: Tg(Tyrp1-cre)1Ipc Location: unknown
• Alliance: Tg(Tyrp1-cre)1Ipc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tyrp1-cre)1Ipc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Tyrp1

• Mutation details: The transgenic construct contained the Tyrp1 promoter region adjoined to 2 rabbit Beta-globin exons and the cre coding region followed by a polyA signal. The Tyrp1 promoter primarily drives expression in the retinal pigment epithelium. Expression was also detected in the ciliary margin of the retina and in the neural retina. Expression was not detected in the embryonic periocular mesenchyme or the choroid. (J:76604)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tyrp1 (species not specified) Summary of all recombinase alleles driven by Tyrp1. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

21 assay results

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tyrp1-cre)1Ipc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76604 Mori M, et al., Site-specific somatic mutagenesis in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2002 May;43(5):1384-8
• All: 21 reference(s)