Fos^tm1Mxu
Targeted Allele Detail

Summary

• Symbol: Fos^tm1Mxu
• Name: FBJ osteosarcoma oncogene; targeted mutation 1, Ming Xu
• MGI ID: MGI:2387304
• Synonyms: f/fc-fos
• Gene: Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
• Alliance: Fos^tm1Mxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75813
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A region containing sequence encoding the DNA-binding and leucine zipper domains and a downstream neo transgene was flanked by single loxP sites. In situ hybridization and immunostaining indicated that the loxP sites did not interfere with transcription or translation. (J:75813)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fos Mutation: 43 strains or lines available

References

• Original: J:75813 Zhang J, et al., c-fos regulates neuronal excitability and survival. Nat Genet. 2002 Apr;30(4):416-20
• All: 14 reference(s)