Usp18^tm1Dez
Targeted Allele Detail

Summary

• Symbol: Usp18^tm1Dez
• Name: ubiquitin specific peptidase 18; targeted mutation 1, Dong-Er Zhang
• MGI ID: MGI:2387336
• Synonyms: UBP43^-, Usp18^LacZ, Usp18^tm1Dzh
• Gene: Usp18 Location: Chr6:121222865-121247876 bp, + strand Genetic Position: Chr6, 57.17 cM, cytoband F
• Alliance: Usp18^tm1Dez page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78821
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4, which contain the translation initiation codon and Cys domain, were replaced with a neo-lacZ cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Western blot analysis of LPS-stimulated thymus glands. (J:78821)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Usp18^tm1Dez

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Usp18 Mutation: 26 strains or lines available

References

• Original: J:78821 Ritchie KJ, et al., Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev. 2002 Sep 1;16(17):2207-12
• All: 26 reference(s)