Dpt^tm1Hsh
Targeted Allele Detail

Summary

• Symbol: Dpt^tm1Hsh
• Name: dermatopontin; targeted mutation 1, Hiroshi Shinkai
• MGI ID: MGI:2387341
• Synonyms: Dpt^-
• Gene: Dpt Location: Chr1:164624232-164651843 bp, + strand Genetic Position: Chr1, 72.12 cM, cytoband H2
• Alliance: Dpt^tm1Hsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78845
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was demonstrated by RT-PCR and Western blot analysis of tail tissues. (J:78845)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dpt Mutation: 16 strains or lines available

References

• Original: J:78845 Takeda U, et al., Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis. J Invest Dermatol. 2002 Sep;119(3):678-83
• All: 3 reference(s)