Adipoq^tm1Ish
Targeted Allele Detail

Summary

• Symbol: Adipoq^tm1Ish
• Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Iichiro Shimomura
• MGI ID: MGI:2387344
• Synonyms: Adipo^-, APN-KO
• Gene: Adipoq Location: Chr16:22965286-22976718 bp, + strand Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
• Alliance: Adipoq^tm1Ish page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77479
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Parts of introns 1 and 2, and regions of exon 2, which contains the translation initiation sites, were replaced by a neomycin resistance gene via homologous recombination. Absence of gene expression in adipose tissues of homozygous mutant animals was confirmed by Northern blot analysis. Protein product was undetectable in plasma of homozygous mutants. (J:77479)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adipoq Mutation: 40 strains or lines available

References

• Original: J:77479 Maeda N, et al., Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med. 2002 Jul;8(7):731-7
• All: 83 reference(s)