Tcf3^tm3Zhu
Targeted Allele Detail

Summary

• Symbol: Tcf3^tm3Zhu
• Name: transcription factor 3; targeted mutation 3, Yuan Zhuang
• MGI ID: MGI:2387352
• Synonyms: E2A^heb
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^tm3Zhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47671
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The E12 and E47 specific exons were replaced by a full length human TCF12 cDNA adjoined to an IRES inserted by homologous recombination. Western blot analysis confirmed that the human gene was expressed. (J:47671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 43 strains or lines available

References

• Original: J:47671 Zhuang Y, et al., Functional replacement of the mouse E2A gene with a human HEB cDNA. Mol Cell Biol. 1998 Jun;18(6):3340-9
• All: 2 reference(s)