Tcf12^tm1Zhu
Targeted Allele Detail

Summary

• Symbol: Tcf12^tm1Zhu
• Name: transcription factor 12; targeted mutation 1, Yuan Zhuang
• MGI ID: MGI:2387400
• Synonyms: HEB^-, HEB^ko
• Gene: Tcf12 Location: Chr9:71751534-72019611 bp, - strand Genetic Position: Chr9, 39.85 cM
• Alliance: Tcf12^tm1Zhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43324
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette deleted sequence encoding the 3' portion of the basic helix-loop-helix (bHLH) domain. The disruption of the bHLH precludes dimerization, thereby preventing the potential for DNA binding activity. (J:43324)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf12 Mutation: 75 strains or lines available

References

• Original: J:43324 Zhuang Y, et al., B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol. 1996 Jun;16(6):2898-905
• All: 15 reference(s)