Stk11^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1Rdp
• Name: serine/threonine kinase 11; targeted mutation 1, Ronald DePinho
• MGI ID: MGI:2387401
• Synonyms: Lkb1^c, Lkb1^f, STK11^fl
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78818
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 through 6 were flanked by single loxP sites inserted into introns 2 and 6. In addition a neo cassette flanked by frt sites was inserted into intron 2, downstream of the loxP site. Mice carrying this allele were used to generate Stk11^tm1.1Rdp and Stk11^tm1.2Rdp. (J:78818)

Disease models

Expression

In Mice Carrying this Mutation:	208072 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk11^tm1Rdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 35 strains or lines available

References

• Original: J:78818 Bardeesy N, et al., Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12;419(6903):162-7
• All: 38 reference(s)