Stk11^tm1.2Rdp
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1.2Rdp
• Name: serine/threonine kinase 11; targeted mutation 1.2, Ronald DePinho
• MGI ID: MGI:2387403
• Synonyms: Lkb1^-
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1.2Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78818
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 6 were excised from Stk11^tm1Rdp via the in vivo expression of cre recombinase. Protein was undetected by Western blot analysis of mouse embyronic fibroblasts derived from homozygous mutant mice. (J:78818)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk11^tm1.2Rdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 35 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Non-Small-Cell Lung Carcinoma J:124682 in double Kras and Stk11 mutants.

References

• Original: J:78818 Bardeesy N, et al., Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12;419(6903):162-7
• All: 15 reference(s)