Cd55^tm1Song
Targeted Allele Detail

Summary

• Symbol: Cd55^tm1Song
• Name: CD55 molecule, decay accelerating factor for complement; targeted mutation 1, Wen-Chao Song
• MGI ID: MGI:2387405
• Synonyms: Daf^-, Daf1-
• Gene: Cd55 Location: Chr1:130366764-130390481 bp, - strand Genetic Position: Chr1, 56.89 cM
• Alliance: Cd55^tm1Song page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52968
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exons 1, 2 and 3, encoding the first and second short consensus repeats, were replaced with a neomycin selection cassette. Transcript was undetected in homozygous mutant mice by Northern blot analysis. (J:52968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cd55 Mutation: 39 strains or lines available

References

• Original: J:52968 Sun X, et al., Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):628-33
• All: 29 reference(s)