Htr1a^tm1Rhn
Targeted Allele Detail

Summary

• Symbol: Htr1a^tm1Rhn
• Name: 5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 1, Rene Hen
• MGI ID: MGI:2387407
• Synonyms: 5-HT1A
• Gene: Htr1a Location: Chr13:105580147-105584630 bp, + strand Genetic Position: Chr13, 56.92 cM
• Alliance: Htr1a^tm1Rhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51280
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a neomycin selection cassette downstream of sequence encoding the third transmembrane domain. Homozygous mutant mice were shown to lack functional receptors via autoradiography studies of brain sections. (J:51280)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr1a Mutation: 26 strains or lines available

References

• Original: J:51280 Ramboz S, et al., Serotonin receptor 1A knockout: an animal model of anxiety-related disorder [see comments]. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14476-81
• All: 32 reference(s)