Htr1a^tm1Toth
Targeted Allele Detail

Summary

• Symbol: Htr1a^tm1Toth
• Name: 5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 1, Miklos Toth
• MGI ID: MGI:2387408
• Synonyms: 5-HT(1A)-KO, 5-HT1A KO
• Gene: Htr1a Location: Chr13:105580147-105584630 bp, + strand Genetic Position: Chr13, 56.92 cM
• Alliance: Htr1a^tm1Toth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49752
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette deleted the start codon and 123 bp of coding sequence. Autoradiograhy analysis showed an absence of binding in coronal sections from homozygous mutant mice. (J:49752)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr1a Mutation: 26 strains or lines available

References

• Original: J:49752 Parks CL, et al., Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10734-9
• All: 15 reference(s)