Htr1a^tm2Rhn
Targeted Allele Detail

Summary

• Symbol: Htr1a^tm2Rhn
• Name: 5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 2, Rene Hen
• MGI ID: MGI:2387416
• Synonyms: Htr1a^KO, Htr1a^tetO
• Gene: Htr1a Location: Chr13:105580147-105584630 bp, + strand Genetic Position: Chr13, 56.92 cM
• Alliance: Htr1a^tm2Rhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75722
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Transcription of the coding region was blocked by the insertion of a neomycin resistance gene and tetO binding sites in the 5' untranslated region. Autoradiography analysis showed an absence of binding in homozygous mutant mice. (J:75722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr1a Mutation: 26 strains or lines available

References

• Original: J:75722 Gross C, et al., Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature. 2002 Mar 28;416(6879):396-400
• All: 7 reference(s)