Tg(Fabp4-cre/ERT2)1Ipc
Transgene Detail

Summary

• Symbol: Tg(Fabp4-cre/ERT2)1Ipc
• Name: transgene insertion 1, I Pierre Chambon
• MGI ID: MGI:2387425
• Synonyms: aP2-Cre-ER^T2, aP2-CreERT2, Tg(Fabp4-cre/Esr1)1Ipc
• Transgene: Tg(Fabp4-cre/ERT2)1Ipc Location: unknown
• Alliance: Tg(Fabp4-cre/ERT2)1Ipc page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Fabp4-cre/ERT2)1Ipc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Fabp4

• Mutation details: The transgenic construct encodes a tamoxifen-inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain. The adipocyte fatty acid-binding protein 4 promoter was used to drive expression in white and brown adipose tissue. (J:66706)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fabp4 (species not specified) Summary of all recombinase alleles driven by Fabp4. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:66706 Imai T, et al., Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):224-8
• All: 19 reference(s)