Tnfsf13b^tm1Msc
Targeted Allele Detail

Summary

• Symbol: Tnfsf13b^tm1Msc
• Name: tumor necrosis factor (ligand) superfamily, member 13b; targeted mutation 1, Martin L Scott
• MGI ID: MGI:2387426
• Synonyms: BAFF^-, BLyS^-
• Gene: Tnfsf13b Location: Chr8:10056637-10086000 bp, + strand Genetic Position: Chr8, 4.55 cM
• Alliance: Tnfsf13b^tm1Msc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71681
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-2 (732 bp of the gene) encoding the first 134 residues were replaced with a human CD2 reporter gene fused to a neomycin resistance cassette. Northern blot analysis of spleen RNA using probes to the deleted region did not detect gene transcript in homozygous mutant animals. (J:71681)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfsf13b Mutation: 30 strains or lines available

References

• Original: J:71681 Schiemann B, et al., An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science. 2001 Sep 14;293(5537):2111-4
• All: 47 reference(s)