Tnfrsf17^tm1Msc
Targeted Allele Detail

Summary

• Symbol: Tnfrsf17^tm1Msc
• Name: tumor necrosis factor receptor superfamily, member 17; targeted mutation 1, Martin L Scott
• MGI ID: MGI:2387427
• Synonyms: BCMA^-
• Gene: Tnfrsf17 Location: Chr16:11131676-11137938 bp, + strand Genetic Position: Chr16, 6.42 cM, cytoband B3
• Alliance: Tnfrsf17^tm1Msc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71681
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region of the gene containing the translation initiation codon and 1.3 kb of downstream sequences were replaced with a human CD2 reporter gene fused to a neomycin resistance cassette. The mutation deletes the first 87 residues, which includes a putative transmembrane domain. Northern blot analysis of spleen RNA using probes to the deleted region did not detect gene transcript in homozygous mutant animals. (J:71681)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf17 Mutation: 21 strains or lines available

References

• Original: J:71681 Schiemann B, et al., An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science. 2001 Sep 14;293(5537):2111-4
• All: 3 reference(s)