Rhob^tm1Gcp
Targeted Allele Detail

Summary

• Symbol: Rhob^tm1Gcp
• Name: ras homolog family member B; targeted mutation 1, George C Prendergast
• MGI ID: MGI:2387429
• Synonyms: RhoB -, RhoB null
• Gene: Rhob Location: Chr12:8547661-8550009 bp, - strand Genetic Position: Chr12, 3.88 cM
• Alliance: Rhob^tm1Gcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• The entire gene was replaced with an IRES-lacZ-PGK-neo cassette via homologous recombination. (J:71577)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rhob^tm1Gcp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhob Mutation: 18 strains or lines available

References

• Original: J:71577 Liu AX, et al., Rhob is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. Mol Cell Biol. 2001 Oct;21(20):6906-12
• All: 19 reference(s)