Tg(SERPINA1-cre/ERT)1Ipc
Transgene Detail

Summary

• Symbol: Tg(SERPINA1-cre/ERT)1Ipc
• Name: transgene insertion 1, I Pierre Chambon
• MGI ID: MGI:2387444
• Synonyms: alphaAT-cre-ER^T, Tg(SERPINA1-cre/ESR1)1Ipc
• Transgene: Tg(SERPINA1-cre/ERT)1Ipc Location: unknown
• Alliance: Tg(SERPINA1-cre/ERT)1Ipc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(SERPINA1-cre/ERT)1Ipc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  SERPINA1 (5265)

  Serpina1a	(MGI:891971)
  Serpina1b	(MGI:891970)
  Serpina1c	(MGI:891969)
  Serpina1d	(MGI:891968)
  Serpina1e	(MGI:891967)

• Mutation details: This transgenic construct encodes a tamoxifen-inducible cre recombinase protein. A human SERPINA1 promoter was adjoined to a sequence encoding a fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain, to drive expression in hepatocytes. The ligand-binding domain possesses a substitution mutation at position 521, converting the region from an estradiol binding domain to a tamoxifen binding domain. In situ hybridization and immunohistochemical analysis showed expression in 40% to 50% of hepatocytes. (J:69327)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	SERPINA1 (human) Summary of all recombinase alleles driven by SERPINA1. Comparative matrix view of recombinase activities Alliance human SERPINA1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:69327 Imai T, et al., Inducible site-specific somatic mutagenesis in mouse hepatocytes. Genesis. 2000 Feb;26(2):147-8
• All: 3 reference(s)