Fn1^tm1Ref
Targeted Allele Detail

Summary

• Symbol: Fn1^tm1Ref
• Name: fibronectin 1; targeted mutation 1, Reinhard Fassler
• MGI ID: MGI:2387457
• Synonyms: Fn(fl), FN^flox
• Gene: Fn1 Location: Chr1:71624679-71692359 bp, - strand Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
• Alliance: Fn1^tm1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67961
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked by loxP sites inserted into the 5' untranslated region and intron 1. The presence of the loxP sites were shown to have no effect on expression, as the levels of mRNA in liver and of protein in plasma, liver, heart, kidney were found to be normal by Northern and Western blot analyses. (J:67961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fn1 Mutation: 130 strains or lines available

References

• Original: J:67961 Sakai T, et al., Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med. 2001 Mar;7(3):324-30
• All: 33 reference(s)