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Catsper1tm1Clph
Targeted Allele Detail
Summary
Symbol: Catsper1tm1Clph
Name: cation channel, sperm associated 1; targeted mutation 1, David E Clapham
MGI ID: MGI:2387461
Synonyms: CatSper-
Gene: Catsper1  Location: Chr19:5385769-5394308 bp, + strand  Genetic Position: Chr19, 4.3 cM, cytoband A
Alliance: Catsper1tm1Clph page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72046
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe second exon coding the first putative transmembrane domain was replaced with an IRES-LacZ sequence followed by the neomycin resistance gene. Western blotting confirmed absence of protein from testis of homozygous mutant mice. (J:72046)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Catsper1 Mutation:  27 strains or lines available
References
Original:  J:72046 Ren D, et al., A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11;413(6856):603-9
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory