Catsper1^tm1Clph
Targeted Allele Detail

Summary

• Symbol: Catsper1^tm1Clph
• Name: cation channel, sperm associated 1; targeted mutation 1, David E Clapham
• MGI ID: MGI:2387461
• Synonyms: CatSper-
• Gene: Catsper1 Location: Chr19:5385769-5394308 bp, + strand Genetic Position: Chr19, 4.3 cM, cytoband A
• Alliance: Catsper1^tm1Clph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72046
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The second exon coding the first putative transmembrane domain was replaced with an IRES-LacZ sequence followed by the neomycin resistance gene. Western blotting confirmed absence of protein from testis of homozygous mutant mice. (J:72046)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Catsper1 Mutation: 27 strains or lines available

References

• Original: J:72046 Ren D, et al., A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11;413(6856):603-9
• All: 27 reference(s)