Rps6^tm1Gtho
Targeted Allele Detail

Summary

• Symbol: Rps6^tm1Gtho
• Name: ribosomal protein S6; targeted mutation 1, George Thomas
• MGI ID: MGI:2387471
• Synonyms: fS6, Rps6^lox, S6^lox
• Gene: Rps6 Location: Chr4:86772897-86775649 bp, - strand Genetic Position: Chr4, 40.69 cM, cytoband C3
• Alliance: Rps6^tm1Gtho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62795
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 through 5 were flanked by a single loxP site inserted into intron 2 and a downstream neo cassette with a 3' loxP site. Northern blot analysis verified that the floxed allele was expressed in liver tissue. (J:62795)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6 Mutation: 12 strains or lines available

References

• Original: J:62795 Volarevic S, et al., Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science. 2000 Jun 16;288(5473):2045-7
• All: 8 reference(s)