Rps6ka3^tm1Ljg
Targeted Allele Detail

Summary

• Symbol: Rps6ka3^tm1Ljg
• Name: ribosomal protein S6 kinase polypeptide 3; targeted mutation 1, Laurie J Goodyear
• MGI ID: MGI:2387473
• Synonyms: Rsk2^-, Rsk2 KO
• Gene: Rps6ka3 Location: ChrX:158038652-158151240 bp, + strand Genetic Position: ChrX, 73.27 cM
• Alliance: Rps6ka3^tm1Ljg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding 31 residues of the amino terminal kinase domain were replaced with a neomycin selection cassette. Western blot analysis of muscle lysates confirmed the absence of normal protein in homozygous mutant mice. (J:67575)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6ka3 Mutation: 13 strains or lines available

References

• Original: J:67575 Dufresne SD, et al., Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Mol Cell Biol. 2001 Jan;21(1):81-7
• All: 8 reference(s)