Zeb2^tm1.2Yhi
Targeted Allele Detail

Summary

• Symbol: Zeb2^tm1.2Yhi
• Name: zinc finger E-box binding homeobox 2; targeted mutation 1.2, Yujiro Higashi
• MGI ID: MGI:2387501
• Synonyms: SIP1^{delta ex7}, Zfhx1b^deltaex7
• Gene: Zeb2 Location: Chr2:44873644-45007407 bp, - strand Genetic Position: Chr2, 27.31 cM, cytoband C1
• Alliance: Zeb2^tm1.2Yhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75138
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 7, which encodes the fourth zinc finger of the amino terminal zinc finger cluster, the Madh binding domain, the homeodomain like sequence, and the CtBP binding sites, were deleted along with a floxed neo cassette by in vivo cre recombination of Zhx1b^tm1Yhi. The absence of protein was confirmed by Western blot analysis of homozygous mutant mice. (J:75138)

Disease models

Expression

In Mice Carrying this Mutation:	30 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zeb2 Mutation: 78 strains or lines available

References

• Original: J:75138 Higashi Y, et al., Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse. Genesis. 2002 Feb;32(2):82-4
• All: 10 reference(s)