Tg(CMV-cre/ERT)1Ipc
Transgene Detail

Summary

• Symbol: Tg(CMV-cre/ERT)1Ipc
• Name: transgene insertion 1, I Pierre Chambon
• MGI ID: MGI:2387570
• Synonyms: CMV-cre, CMV-Cre-ER^T, CMV-CRE-ER-Tx, Cre-ER^T, CRE-ER-Tx, Tg(CMV-cre/ESR1)1Ipc
• Transgene: Tg(CMV-cre/ERT)1Ipc Location: unknown
• Alliance: Tg(CMV-cre/ERT)1Ipc page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(CMV-cre/ERT)1Ipc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  virus	CMV

• Mutation details: The transgenic construct encodes a tamoxifen-dependent cre recombinase. The cre recombinase coding region was joined to a sequence encoding the ligand-binding domain of the human estrogen receptor with glycine to arginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability. The transgene was driven by the CMV promoter. (J:79245)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CMV (virus) Summary of all recombinase alleles driven by CMV.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:79245 Feil R, et al., Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10887-90
• All: 23 reference(s)