Kif1b^tm1Noh
Targeted Allele Detail

Summary

• Symbol: Kif1b^tm1Noh
• Name: kinesin family member 1B; targeted mutation 1, Nobutaka Hirokawa
• MGI ID: MGI:2387573
• Synonyms: kif1B^-
• Gene: Kif1b Location: Chr4:149260776-149392150 bp, - strand Genetic Position: Chr4, 79.05 cM, cytoband E
• Alliance: Kif1b^tm1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69772
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the ATP binding consensus P loop of the motor domain was replaced with a neomycin cassette by homologous recombination. Western blot analysis of brain crude extracts showed both the alpha and beta isoforms to be absent in homozygous mice. (J:69772)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif1b Mutation: 128 strains or lines available

References

• Original: J:69772 Zhao C, et al., Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001 Jun 1;105(5):587-97
• All: 3 reference(s)