Igh-7^tm1Led
Targeted Allele Detail

Summary

• Symbol: Igh-7^tm1Led
• Name: immunoglobulin heavy chain 7 (heavy chain of IgE); targeted mutation 1, Philip Leder
• MGI ID: MGI:2387579
• Synonyms: IgE^-
• Gene: Igh-7 Location: Chr12:113228142-113241336 bp Genetic Position: Chr12, Syntenic
• Alliance: Igh-7^tm1Led page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19552
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 4 were replaced by a neomycin selection cassette inserted via homologous recombination. Transcript was undetected by Northern blot analysis of splenocytes obtained from homozygous mutant mice and stimulated with interleukin-4 and LPS. ELISA confirmed the absence of IgE. (J:19552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igh-7 Mutation: 1 strain or line available

References

• Original: J:19552 Oettgen HC, et al., Active anaphylaxis in IgE-deficient mice. Nature. 1994 Aug 4;370(6488):367-70
• All: 27 reference(s)