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Pou4f1tm1Nat
Targeted Allele Detail
Summary
Symbol: Pou4f1tm1Nat
Name: POU domain, class 4, transcription factor 1; targeted mutation 1, Jeremy Nathans
MGI ID: MGI:2387665
Synonyms: Brn-3a-
Gene: Pou4f1  Location: Chr14:104699112-104705435 bp, - strand  Genetic Position: Chr14, 54.21 cM, cytoband E1-E3
Alliance: Pou4f1tm1Nat page
Behavioral differences between +/+ wild-type and Pou4f1tm1Nat/Pou4f1tm1Nat mice at birth

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:35877
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region of the endogenous locus was replaced with a neomycin selection cassette inserted by homologous recombination. Immunohistochemical analysis of retinal tissue verified that protein was not produced by the targeted locus. (J:35877)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 179 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou4f1 Mutation:  13 strains or lines available
References
Original:  J:35877 Xiang M, et al., Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11950-5
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory