Fzd4^tm1Nat
Targeted Allele Detail

Summary

• Symbol: Fzd4^tm1Nat
• Name: frizzled class receptor 4; targeted mutation 1, Jeremy Nathans
• MGI ID: MGI:2387667
• Synonyms: fz4(-), Fz4^lacZ
• Gene: Fzd4 Location: Chr7:89053574-89062341 bp, + strand Genetic Position: Chr7, 49.32 cM
• Alliance: Fzd4^tm1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70078
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing lacZ and neo was inserted at the start codon of the endogenous locus via homologous recombination. The inserted sequences replaced all but the last 70 bp of the protein coding region. Expression of beta-galactosidase was visualized by X-gal staining. (J:70078)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd4 Mutation: 31 strains or lines available

References

• Original: J:70078 Wang Y, et al., Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. J Neurosci. 2001 Jul 1;21(13):4761-71
• All: 18 reference(s)