Hmgb2^tm1Meb
Targeted Allele Detail

Summary

• Symbol: Hmgb2^tm1Meb
• Name: high mobility group box 2; targeted mutation 1, Marco E Bianchi
• MGI ID: MGI:2387671
• Synonyms: Hmgb2^-
• Gene: Hmgb2 Location: Chr8:57964941-57969033 bp, + strand Genetic Position: Chr8, 29.9 cM
• Alliance: Hmgb2^tm1Meb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of 741 bp of genomic sequence with a ble-lacZ cassette starting from the ATG initiation codon in exon 2 and ending in exon 4. Absence of gene expression in homozygous mutant animals was confirmed by immunoblot of total testis extract using chicken anti-Hmgb2 antibodies. (J:67968)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgb2 Mutation: 12 strains or lines available

References

• Original: J:67968 Ronfani L, et al., Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2. Development. 2001 Apr;128(8):1265-73
• All: 9 reference(s)