Thrsp^tm1Cnm
Targeted Allele Detail

Summary

• Symbol: Thrsp^tm1Cnm
• Name: thyroid hormone responsive; targeted mutation 1, Cary N Mariash
• MGI ID: MGI:2387689
• Gene: Thrsp Location: Chr7:97062140-97066757 bp, - strand Genetic Position: Chr7, 53.49 cM, cytoband E3
• Alliance: Thrsp^tm1Cnm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71785
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a large portion of exon 1 with a PGK-neo cassette. The targeted mutation deletes sequences encoding amino acids 22-150. Northern blot analysis and quantitative RT-PCR was unable to detect gene transcripts from hepatic mRNA of homozygous mutant animals, thus confirming the null allele. (J:71785)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thrsp Mutation: 13 strains or lines available

References

• Original: J:71785 Zhu Q, et al., Spot 14 Gene Deletion Increases Hepatic de Novo Lipogenesis. Endocrinology. 2001 Oct;142(10):4363-70
• All: 6 reference(s)