Tg(tetO-HRAS)65Lc
Transgene Detail

Summary

• Symbol: Tg(tetO-HRAS)65Lc
• Name: transgene insertion 65, Lynda Chin
• MGI ID: MGI:2387692
• Synonyms: Tet-Ras
• Transgene: Tg(tetO-HRAS)65Lc Location: unknown
• Alliance: Tg(tetO-HRAS)65Lc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Constitutively active, Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The transgene carries a cDNA encoding an activated human HRAS protein (G12V) under the control of a minimal promoter containing multimerized tet-operons. (J:71333)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:71333 Chin L, et al., Essential role for oncogenic Ras in tumour maintenance. Nature. 1999 Jul 29;400(6743):468-72
• All: 16 reference(s)