Nudt1^tm1Tts
Targeted Allele Detail

Summary

• Symbol: Nudt1^tm1Tts
• Name: nudix hydrolase 1; targeted mutation 1, Teruhisa Tsuzuki
• MGI ID: MGI:2387695
• Synonyms: MTH1-
• Gene: Nudt1 Location: Chr5:140307411-140323892 bp, + strand Genetic Position: Chr5, 78.94 cM, cytoband G1
• Alliance: Nudt1^tm1Tts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71836
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 3 and flanking intronic regions with a neomycin resistance cassette. Western blot analysis and enzyme assay of liver samples confirmed the absence of gene expression in homozygous mutant animals. (J:71836)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nudt1^tm1Tts

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nudt1 Mutation: 31 strains or lines available

References

• Original: J:71836 Tsuzuki T, et al., Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11456-61
• All: 12 reference(s)