Axl^tm1Grl
Targeted Allele Detail

Summary

• Symbol: Axl^tm1Grl
• Name: AXL receptor tyrosine kinase; targeted mutation 1, Greg Lemke
• MGI ID: MGI:2387750
• Synonyms: Axl-
• Gene: Axl Location: Chr7:25456698-25488130 bp, - strand Genetic Position: Chr7, 14.02 cM, cytoband A3-B1
• Alliance: Axl^tm1Grl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54681
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a segment of the gene containing exon 9. Western blot analysis on total brain lysates derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:54681)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Axl^tm1Grl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Axl Mutation: 60 strains or lines available

References

• Original: J:54681 Lu Q, et al., Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature. 1999 Apr 22;398(6729):723-8
• All: 75 reference(s)