Dkk1^tm1Lmgd
Targeted Allele Detail

Summary

• Symbol: Dkk1^tm1Lmgd
• Name: dickkopf WNT signaling pathway inhibitor 1; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
• MGI ID: MGI:2387760
• Synonyms: Dkk1-
• Gene: Dkk1 Location: Chr19:30523276-30526896 bp, - strand Genetic Position: Chr19, 25.16 cM, cytoband C2
• Alliance: Dkk1^tm1Lmgd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71787
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutants were identified by Southern blot analysis. (J:71787)

Expression

In Mice Carrying this Mutation:	315 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dkk1 Mutation: 18 strains or lines available

References

• Original: J:71787 Mukhopadhyay M, et al., Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell. 2001 Sep;1(3):423-34
• All: 29 reference(s)