Tyro3^tm1Grl
Targeted Allele Detail

Summary

• Symbol: Tyro3^tm1Grl
• Name: TYRO3 protein tyrosine kinase 3; targeted mutation 1, Greg Lemke
• MGI ID: MGI:2387762
• Synonyms: Rse^-, Tyro3, Tyro3^-/-V1
• Gene: Tyro3 Location: Chr2:119628214-119648585 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband F
• Alliance: Tyro3^tm1Grl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54681
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced sequences containing exon 9 and part of exon 10. Western blot analysis on brain lysates derived from homozygous mice confirmed that no detectable protein was produced from this allele. (J:54681)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyro3 Mutation: 42 strains or lines available

References

• Original: J:54681 Lu Q, et al., Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature. 1999 Apr 22;398(6729):723-8
• All: 44 reference(s)