H2az1^tm1Ily
Targeted Allele Detail

Summary

• Symbol: H2az1^tm1Ily
• Name: H2A.Z variant histone 1; targeted mutation 1, Ian Lyons
• MGI ID: MGI:2387764
• Synonyms: H2A.Z^-
• Gene: H2az1 Location: Chr3:137570248-137572683 bp, + strand Genetic Position: Chr3, 63.94 cM
• Alliance: H2az1^tm1Ily page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71146
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter regions and exons 1 and 2 were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant embryos were detected by PCR genotyping up to day E6.5. (J:71146)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2az1 Mutation: 13 strains or lines available

References

• Original: J:71146 Faast R, et al., Histone variant H2A.Z is required for early mammalian development. Curr Biol. 2001 Aug 7;11(15):1183-7
• All: 1 reference(s)