Mertk^tm1Grl
Targeted Allele Detail

Summary

• Symbol: Mertk^tm1Grl
• Name: MER proto-oncogene tyrosine kinase; targeted mutation 1, Greg Lemke
• MGI ID: MGI:2387765
• Synonyms: Mer^-, Mertk^-
• Gene: Mertk Location: Chr2:128540876-128644814 bp, + strand Genetic Position: Chr2, 62.63 cM
• Alliance: Mertk^tm1Grl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54681
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 18 of the gene, which encodes part of the kinase domain known to be essential for tyrosine kinase function. An RNase protection assay demonstrated that a mutant transcript was expressed that lacked the deleted sequences. (J:54681)
• Inheritance: Not Specified

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mertk^tm1Grl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mertk Mutation: 65 strains or lines available

References

• Original: J:54681 Lu Q, et al., Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature. 1999 Apr 22;398(6729):723-8
• All: 93 reference(s)