Plk4^tm1Jwd
Targeted Allele Detail

Summary

• Symbol: Plk4^tm1Jwd
• Name: polo like kinase 4; targeted mutation 1, James W Dennis
• MGI ID: MGI:2387766
• Synonyms: Plk4^-, Sak^-
• Gene: Plk4 Location: Chr3:40754463-40771318 bp, + strand Genetic Position: Chr3, 19.54 cM
• Alliance: Plk4^tm1Jwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68142
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin resistance cassette via homologous recombination. The targeted mutation deletes the translation initiation site and part of the kinase domain. (J:68142)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plk4 Mutation: 38 strains or lines available

References

• Original: J:68142 Hudson JW, et al., Late mitotic failure in mice lacking Sak, a polo-like kinase. Curr Biol. 2001 Mar 20;11(6):441-6
• All: 5 reference(s)