Nmbr^tm1Hoh
Targeted Allele Detail

Summary

• Symbol: Nmbr^tm1Hoh
• Name: neuromedin B receptor; targeted mutation 1, Hiroko Ohki-Hamazaki
• MGI ID: MGI:2387767
• Synonyms: NBR^-
• Gene: Nmbr Location: Chr10:14634894-14647202 bp, + strand Genetic Position: Chr10, 5.5 cM, cytoband A2
• Alliance: Nmbr^tm1Hoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52410
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neomycin selection cassette inserted by homologous recombination. The absence and functional ablation of the receptor were confirmed by RT-PCR analysis and binding assays. (J:52410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmbr Mutation: 22 strains or lines available

References

• Original: J:52410 Ohki-Hamazaki H, et al., Functional properties of two bombesin-like peptide receptors revealed by the analysis of mice lacking neuromedin B receptor. J Neurosci. 1999 Feb 1;19(3):948-54
• All: 15 reference(s)