Mertk^tm1Gkm
Targeted Allele Detail

Summary

• Symbol: Mertk^tm1Gkm
• Name: MER proto-oncogene tyrosine kinase; targeted mutation 1, Glenn K Matsushima
• MGI ID: MGI:2387768
• Synonyms: Mer^-, mer^kd, MERKO, mertk^kd, Mertk^-/-V1
• Gene: Mertk Location: Chr2:128540876-128644814 bp, + strand Genetic Position: Chr2, 62.63 cM
• Alliance: Mertk^tm1Gkm page

Mononuclear cell infiltration of the large intestines and salivary glands are reduced in Mertk^tm1Gkm/Mertk^tm1Gkm mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53423
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequences including the last exon, which encodes the carboxy terminal end of the kinase domain and the cytoplasmic tail. RT-PCR analysis demonstrated that a mutant transcript was expressed from this allele that lacked sequences encoding the cytoplasmic kinase domain. (J:53423, J:153843)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mertk Mutation: 65 strains or lines available

References

• Original: J:53423 Camenisch TD, et al., A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock. J Immunol. 1999 Mar 15;162(6):3498-503
• All: 49 reference(s)